C. Dewey Buescher
Towards the fundamental understanding of hemodynamics in vein and venous valve system: an experimental study.
Year Started: Spring 2003
Anticipated Graduation: Spring 2007
Advisor: Dr. Karlene A. Hoo
B.S. Chemical Engineering, Texas tech University, Lubbock, TX, May, 2000.
A major goal of this project is to develop an improved phenomenological understanding of the basics of hemodynamics in the vein and venous valves through computer aided visualization and measurements of pressure and mass flowrate through the the venous valve. Experiments will be conducted in vitro (harvested veins) and in situ using both fiber optic techniques, external visualization and LabView® data acquisition techniques. Ultimately, we hope to develop a mechanical model based on the measurements and theoretical understanding of the hemodynamic mechanisms of the venous system so that flow patterns can be predicted with a known degree of certainty at a wide range of conditions. After this is completed, we will be able to use this model to understand the associations between venous/valve function and basic systemic biological activities, such as blood circulation, under different physiologic transport conditions that may lead to chronic venous insufficiency and deep venous thrombosis.
Progress to Date:
Refereed Manuscripts: For reprints contact K. A. Hoo (firstname.lastname@example.org)
Buescher, C. D., B. Nachiappan, J. Brumbaugh, K. A. Hoo, and H. F Jansen, "Experimental Studies of the Effects of Abnormal Bicuspid Valves on Fluid Flow," BioTechnology Progress, Vol. 21, pp 938-945, 2005.
Buescher, C. D., K. A. Hoo, and H. F Janssen ``An Experimental Approach to Measure Mass Transport in Rat Tumor Tissue,'' under review BioTechnology Progress, August 2006.
Buescher, C. D., K. A. Hoo, and H. F Janssen ``An Experimental Approach to Measure Mass Transport in Rat Tumor Tissue,'' under review to IEEE Trans. Biomedical Engineering, July, 2007 .
Invited Conference Abstracts :
Buescher, C.D. and K.A. Hoo, "Experimental Evaluation of the Physiologic Response of the Venous Valve", 2004 AIChE national meeting, Austin, TX.
Buescher, C.D, N.S. Wijeratne, K.A. Hoo, and H.F.Janssen, "Determining the Effects of Heterogeneous Mass Transfer Characteristics of Tumor Tissue in a Constitutive Model,'' 2005 AIChE national meeting, Cincinnati, OH.
Buescher, C.D, K.A. Hoo, and H.F.Janssen, "Experimental characterization of in vitro venous valve and venous tissue", 2007 AIChE Annual meeting, Salt Lake City, UT.
*Address all inquiries to Dr. Karlene Hoo